C-fos induced growth factor

C-fos induced growth factor (vascular endothelial growth factor D)

Identifiers

FIGF; VEGF-D; VEGFD

External IDs

OMIM: 300091 MGI: 108037 HomoloGene: 3288 GeneCards: FIGF Gene

Gene Ontology
Molecular function	• platelet-derived growth factor receptor binding • growth factor activity • chemoattractant activity
Cellular component	• extracellular region • extracellular space • membrane • platelet alpha granule lumen
Biological process	• angiogenesis • platelet degranulation • multicellular organismal development • blood coagulation • positive regulation of cell proliferation • cell differentiation • platelet activation • vascular endothelial growth factor receptor signaling pathway • positive chemotaxis • induction of positive chemotaxis • positive regulation of cell division • positive regulation of mast cell chemotaxis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
15.36 – 15.4 Mb

Chr X:
160.81 – 160.84 Mb

PubMed search

[1]

[2]

C-fos induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene.^[1]

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor C.^[1]

References

^ ^a ^b "Entrez Gene: FIGF c-fos induced growth factor (vascular endothelial growth factor D)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2277.

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Achen MG, Jeltsch M, Kukk E et al. (1998). "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)". Proc. Natl. Acad. Sci. U.S.A. 95 (2): 548–53. doi:10.1073/pnas.95.2.548. PMC 18457. PMID 9435229. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18457.
Rocchigiani M, Lestingi M, Luddi A et al. (1998). "Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes". Genomics 47 (2): 207–16. doi:10.1006/geno.1997.5079. PMID 9479493.
Stacker SA, Stenvers K, Caesar C et al. (1999). "Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers". J. Biol. Chem. 274 (45): 32127–36. doi:10.1074/jbc.274.45.32127. PMID 10542248.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
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Yokoyama Y, Charnock-Jones DS, Licence D et al. (2003). "Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma". Br. J. Cancer 88 (2): 237–44. doi:10.1038/sj.bjc.6600701. PMC 2377043. PMID 12610509. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2377043.
Rissanen TT, Markkanen JE, Gruchala M et al. (2003). "VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses". Circ. Res. 92 (10): 1098–106. doi:10.1161/01.RES.0000073584.46059.E3. PMID 12714562.
Funaki H, Nishimura G, Harada S et al. (2003). "Expression of vascular endothelial growth factor D is associated with lymph node metastasis in human colorectal carcinoma". Oncology 64 (4): 416–22. doi:10.1159/000070301. PMID 12759540.
Orlandini M, Semboloni S, Oliviero S (2004). "Beta-catenin inversely regulates vascular endothelial growth factor-D mRNA stability". J. Biol. Chem. 278 (45): 44650–6. doi:10.1074/jbc.M304255200. PMID 12920128.
McColl BK, Baldwin ME, Roufail S et al. (2003). "Plasmin Activates the Lymphangiogenic Growth Factors VEGF-C and VEGF-D". J. Exp. Med. 198 (6): 863–8. doi:10.1084/jem.20030361. PMC 2194198. PMID 12963694. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2194198.
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Growth factors

Fibroblast	FGF receptor ligands: FGF1/FGF2/FGF5 · FGF3/FGF4/FGF6 · KGF (FGF7/FGF10/FGF22) · FGF8/FGF17/FGF18 · FGF9/FGF16/FGF20 FGF homologous factors: FGF11 · FGF12 · FGF13 · FGF14 hormone-like: FGF19 · FGF21 · FGF23

EGF-like domain	TGF-α · EGF · HB-EGF

TGFβ pathway	TGF-β (TGF-β1, TGF-β2, TGF-β3)

Insulin-like	IGF-1 · IGF-2

Platelet-derived	PDGFA · PDGFB · PDGFC · PDGFD

Vascular endothelial	VEGF-A · VEGF-B · VEGF-C · VEGF-D · PGF

Other	Nerve · Hepatocyte

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

C-fos induced growth factor

References

Further reading